A RETROSPECTIVE OBSERVATIONAL STUDY ON RECEPTOR STATUS AND CO- MORBIDITIES OR HISTORY OF THYROID DISORDERS AND/OR GALLBLADDER STONES ASSOCIATED WITH BREAST CANCER PATIENTS

Breast cancer is the commonest cancer found in females and has been increasing alarmingly in India since the last decade or so. In order to understand the risk factors associated with this disease, an observational retrospective study was done on total 110 registered breast cancer patients of the age group 18 to 65 from Jawaharlal Nehru Cancer Hospital and Research Centre (JNCHRC), Bhopal. Patients files from the hospital were analyzed in detail for clinical and pathological information including hormone receptor (HR) status. Medical history with a special focus on co-morbidities like thyroid disorders and gallbladder stone history was recorded. These two diseases have been linked to breast cancer development and the present observational study was aimed to throw light into this connection. Out of the 110 breast cancer patients, the receptor most prevalent was Er+ (39%) followed by Her2+ (30%) and Pr+ (26%). There were 33% triple negative cases and only 7% were triple positive. It was found that out of 110 breast cancer patients 59% had thyroid disorders and 32% had gall bladder disease/stones. A long-term large-scale population-based study is required to come to a firm conclusion to find a link so that aggressive measures could be taken to prevent cancer development in these hi gh-risk categories of females.