Dimethoate (Rogor 30 % EC) Induced Histopathological Changes in Thyroid Gland of Female Rattus Rattus Norvigicus

There is a considerable effect on biological system and environment due to dimethoate exposure. The purpose of the present study was to investigate the effect of dimethoate (an organophosphate pesticide) on histopathological changes in thyroid gland female rat, for which total twenty animals were divided into 2 groups of 10 each; each group were further divided in to two sub groups for 15 and 30 days. The first group was served as a control administered with daily dose of vehicle olive oil orally by the help of cannula; the second group was exposed with daily dose of dimethoate ( rogor 30 % EC) dissolved in olive oil by the help of cannula. The histopathological changes in thyroid gland of ?15 days-dimethoate treated group? showed hypertrophied cells and enlarged nuclei, low colloidal epithelial cells and few degenerative changes in epithelial cells. These changes were more prominent in ?30 days-treated group? characterized by more damaged follicle joined together and a lot of follicles expanded and contained abundant basophilic cytoplasm as compared to 15 days and control groups. In conclusion, it is established that dimethoate induced architectural changes in female rat and may be a direct effect of dimethoate of dimethoate on acetylecholineestrase.