Significance of LDH in Severity of Hypertensive Disorders of Pregnancy

Background: Hypertensive Disorders of Pregnancy (HDP) is the most significant problem in obstetrics. They represent one of the most common problems of pregnancy and lead to increased maternal and perinatal morbidity and mortality. Preeclampsia is a multisystem and multifactorial disease and causes cellular death. Aim: To study the significance of LDH in Hypertensive Disorders of Pregnancy (HDP). Materials and methods: This isa comparative study conducted in the Department of OBG, KIMS Hospital and Research Center. Eighty patients were enrolled for the study, Group A (cases)-40 patients of hypertensive disorders of pregnancy and Group B (controls)-40 normotensive controls, these 40 normotensive controls were properly matched with group A with respect to age and gestational age. All patients in group A and B were subjected to lactate dehydrogenase. The collected data were analyzed with IBM.SPSS statistics software 23.0 Version. Results: In group A, 45% were gestational hypertensive patients, 35% were preeclamptic patients, 12.5% eclampsia, 7.5% chronic hypertension. In the present study LDH was increased in 7.5 % in patients with hypertensive disorder of pregnancy. LDH levels were found to be increased in cases of severe preeclampsia with HELLP syndrome, end organ damage and none of the patients with gestational hypertension and normotensives had raised LDH levels. Conclusion: Our study concludes that LDH helps us know the severity of Hypertensive Disorders of Pregnancy (HDP).