Synthesis and Study Impaction Antibacterial, Antifungal Activity Newly Pyridazine and 1,2,4-Triazine Derivatives
Journal: Chemical Methodologies (Vol.6, No. 4)Publication Date: 2022-04-01
Authors : Mohammed Hasan Mohammed Al-Dahlaki; Suaad M.H. Al-Majidi;
Page : 269-279
Keywords : Carbazole; Pyridazine; 1; 2; 4-Triazine; anti-microbial;
Abstract
In this research study, the synthesis sequence of novel pyridazine and 1,2,4-Triazine derivatives was determined by reacting α-hydrazino-N-Carbazole acetamide (1) with acid anhydride derivatives used glacial acetic acid as a solvent to prepare compounds (2-9) pyridazine derivatives reacted compound (1) with phenyl isocyanate, phenyl thioisocyanate, and α-naphthyl isocyanate to use absolute ethanol as solvent to give compounds (10-12). Compounds (10-12) were condensed with (2N. NaOH) to give compounds (14-16) to denominate 1,2,4-Triazine derivatives. Reacted compound (1) with CS2/KOH used absolute ethanol as solvent to provide potassium salt (13). This salt reacts with 95% hydrazine hydrate to give compound (17). The newly synthesized compounds were tested against different microorganisms to evaluate their antimicrobial activities on bacterial strains, gram-positive bacteria, gram-negative bacteria, and fungal strains to identify the most efficient biologically active compounds.
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