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Synthesis and Study Impaction Antibacterial, Antifungal Activity Newly Pyridazine and 1,2,4-Triazine Derivatives

Journal: Chemical Methodologies (Vol.6, No. 4)

Publication Date:

Authors : ; ;

Page : 269-279

Keywords : Carbazole; Pyridazine; 1; 2; 4-Triazine; anti-microbial;

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Abstract

In this research study, the synthesis sequence of novel pyridazine and 1,2,4-Triazine derivatives was determined by reacting α-hydrazino-N-Carbazole acetamide (1) with acid anhydride derivatives used glacial acetic acid as a solvent to prepare compounds (2-9) pyridazine derivatives reacted compound (1) with phenyl isocyanate, phenyl thioisocyanate, and α-naphthyl isocyanate to use absolute ethanol as solvent to give compounds (10-12). Compounds (10-12) were condensed with (2N. NaOH) to give compounds (14-16) to denominate 1,2,4-Triazine derivatives. Reacted compound (1) with CS2/KOH used absolute ethanol as solvent to provide potassium salt (13). This salt reacts with 95% hydrazine hydrate to give compound (17). The newly synthesized compounds were tested against different microorganisms to evaluate their antimicrobial activities on bacterial strains, gram-positive bacteria, gram-negative bacteria, and fungal strains to identify the most efficient biologically active compounds.

Last modified: 2022-03-18 17:13:30