SYNTHESIS AND BIOLOGICAL EVALUATION OF (3S)-3-[4-METHOXYMETHOXY) BENZYL] MORPHOLINE DERIVATIVES FROM L-TYROSINE

Abstract: Morpholine backbone is essential in different pharmacologically active synthetic compounds. Present work is synthesis of novel morpholine nucleus based compounds such as (3S)-3-[4-(methoxymethoxy) benzyl] morpholine and their derivatives (3 I ? 3 O). The compounds were synthesized in multistep reaction with more efficient process starting from L-Tyrosine as key starting material. The moiety L-Tyrosine is commercially available and is also available from Sigma-Aldrich. The chemical structures of the synthesized compounds were confirmed by means of 1HNMR and mass spectral data. High yield and high purity indicates lack of side reaction and by product. The synthesized compounds were then examined for their antibacterial and antifungal activities. Some of them were found to possess good antibacterial and antifungal activity. Keywords: Morpholine, Tyrosine, Antibacterial, Antifungal Activity.