THE MITOCHONDRIAL SUGAR DISEASE AND MOLECULAR MECHANISM
Journal: International Education and Research Journal (Vol.6, No. 3)Publication Date: 2020-03-15
Authors : Raghavendra Rao M.V Abrar A. Khan Mohammed Khaleel Khizer Hussain Junaidy Amreen Hamza Mahendra Kumar Verma Kumar Ponnusamy Dorababu P. Dilip Mathai;
Page : 44-48
Keywords : Diabetes and deafness (DAD); Sensorineural hearing loss.Cardiomyopathy; Adenosine deaminase; Glucokinase gene in type 2 diabetes mellitus;
Abstract
Mitochondria are the power factories of the cells and produce ATP by oxidizing reducing equivalents via the respiratory chain. These reducing equivalents originate mainly from the citric acid cycle that also occurs within the mitochondria. Human mitochondria contain their own genetic material in the form of circular DNA that encodes for only a fraction of the mitochondrial components. The other mitochondrial components are nuclear encoded. Furthermore, the respiratory chain and mitochondrionassociated monoamine oxidase are major producers of reactive oxygen radicals. As a result, mutations in mtDNA can deregulate multiple processes within cells and the balance of this deregulation may contribute to the clinical phenotype Mitochondrial diabetes affects up t
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