GRANULOSA TUMORS: ABOUT 10 CASES

Granulosa tumors arise from the mesenchyme and sex cords of the ovary. They are quite rare. Theyrepresent 0.6 to 3% of all ovarian tumors and 5% of ovarian malignancies. They are the mostfrequent tumors of the sexual cords and stroma. The purpose of our study:To describe the epidemiological, anatomical-clinical and evolutionary characteristics of granulosatumors and to study the different prognostic factors. Materials and methods:Our retrospective study covers 10 cases of ovarian granulosa tumor diagnosed at the gynecologyobstetrics department of the CHU Mohammed VI of Oujda. Over a period of 5 years, from September2016 to September 2021. Results:- The average age of onset of the adult form is 58.4 years (35-38-52-57-66-81). And that of theoccurrence of the juvenile form, is 18.6 years (18-19-22-31).Clinical signs were mainly dominated by abdominal distension, chronic abdominal-pelvic pain andmetrorrhagia.All patients had clinically palpable pelvic tumors.Suprapubic pelvic ultrasound was performed in all our patients.It allowed to link the pelvic mass to its adnexal origin, with an average size, 141.5mm, variablebetween 63mm and 220mm. The CT scan was performed in all our patients. It allowed us to determine the size of the masses andtheir relationship with the surrounding structures.The histological study concluded in a granulosa tumor adult type in 60% of the cases and in agranulosa tumor juvenile type in 40% of the cases.80% of patients received conservative treatment, 20% received radical treatment.60% of our patients have received chemotherapy.No patient had radiotherapy. One patient had a recurrence and all patients are still alive after surgical treatment. Conclusion: Granulosa tumors are rare, of the group of tumors of the sexual cords and the ovarian stroma. The adult forms are of slow evolution, often diagnosed at an early stage are potentially malignant tumors, the recurrences often very late (10-20 years) their treatment is based essentially on surgery more or less chemotherapy. Juvenile forms, rare (5%) with good prognosis. Prolonged post-therapy follow-up is necessary because of late recurrences for Adult forms, frequent and early for juvenile forms.