Inducible Nitric Oxide Synthase Expression in Brain Injury Cases | Biomedgrid
Journal: American Journal of Biomedical Science & Research (Vol.7, No. 3)Publication Date: 2020-02-11
Authors : Bander Khalid Al-rais;
Page : 245-248
Keywords : Inducible Nitric Oxide Synthase; Traumatic Brain Injury; Central Nervous System; Inflammatory disease;
Abstract
Background: The activity of Inducible Nitric Oxide Synthase (iNOS) is increased as a response to several insults to central nervous system causing brain injury. Objectives: To investigate iNOS expression in cadavers who died as result of traumatic brain injury (TBI), brain hemorrhage and brain congestion. Methodology: Indirect immunohistochemistry was performed on 80 cases of brain injury (autopsies), as well 23 normal brain cases as a control group. The cases were stained for iNOS and interpreted in terms of staining intensity from 0 to indicate negative, 1 weak, 2 moderate and 3 to indicate strong staining reactions. Results: personal variables (age, sex, brain weight) were not associated significantly with brain injury type. The iNOS was not express in control group. But, strong activity of iNOS was expressed in neurons astrocytes and in cases of TBI and brain hemorrhage. The activity of iNOS in blood vessels was moderate. The rate of expression of iNOS in congestion cases was low in comparison with TBI and hemorrhage cases. Conclusion: The activity of iNOS was shown to be significantly correlated with TBI and hemorrhage. Strong reactions were localized within neurons and astrocytes. This possibly explains the mediated effects of iNOS on brain blood vessels in terms of blood vessels dilatation to accommodate with the severity of brain injury cases.
Other Latest Articles
- Rapid Seizure Classification Using Feature Extraction and Channel Selection | Biomedgrid
- Antimicrobial Activities of Irvingia gabonensis Leaf and Cyperus esculentus Extracts on Some Selected Isolates | Biomedgrid
- Investigating the Effect of Organizational Structure on Knowledge Absorption Capacity through Organizational Energy Mediation (Case study: Directorate of Education of Astara, Iran)
- A Study of the Representation of the Conceptual Metaphor of Corona in the Afghan Media (Based on the Corona Headlines of the Hasht-e Subh [8 am] Daily)
- Lack of Law on Animal Rights from a Legal Perspective and Psychology
Last modified: 2022-06-11 16:41:22