Epigenetic Mechanisms of Drug Resistance of Non-tuberculous Mycobacteria

High-performance pyrosequencing of the M. abscessus genome was carried out. The genome contains genes responsible for the functioning of the restriction-modifying system; the HPA2 gene encoding histone acetyltransferase HPA2 and related acetyltransferases; cda gene encoding deoxycytidine triphosphate deaminase that is, a complex of perfect epigenetic mechanisms that can protect mycobacteria from various influences, including drug attack.