Formulation Development and Evaluation of Mouth Dissolving Tablet of Thiocolchicoside

The present study was aimed to formulate and evaluate the Mouth dissolving tablet of Thiocolchicoside. Preliminary investigation of drug was carried out with different. Compatibility of drug with polymers was confirmed by FT IR study. Tablet were prepared with superdisintegrants like Sodium starch glycolate, and other ingredients such as Mannitol, Lactose, Maltose. Sodium saccharide and Talc by Direct compression technique. It was observed that the results obtained after evaluation of F2 formulations follows standards prescribed for Mouth dissolving tablets. The tablet was evaluated for various evaluation parameters such as. Weight Variation. Thickness. Hardness, Friability, wetting time, water absorption ratio, In vitro Disintegration Time, in Vitro drug release study, and uniformity of Content etc. Mouth dissolving tablet of optimized formulation F2 having Mouth disintegration, better dissolution and all necessary parameter within the range. Formulation F2 shows the highest drug release upto 99.63 . Finally it is concluded that the drug release from the Mouth dissolving tablet was increased by using the increased concentration of superdisintegrant upto certain conc. After increase in cone. Of superdisintegrant leads to decrease disintegration in the buccal cavity. Increased systemic availability of drug will lead to quick onset of action, which is a prerequisite for analgesic activity. Sujeet A Korde "Formulation Development and Evaluation of Mouth Dissolving Tablet of Thiocolchicoside" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5 , August 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50506.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/50506/formulation-development-and-evaluation-of-mouth-dissolving-tablet-of-thiocolchicoside/sujeet-a-korde