Anti-Psoriatic Activity of Idi Valladhi Mezhugu in Psoriasis (HaCaT) Cell Lines Study - In Vitro

Psoriasis is a chronic, multisystem inflammatory disease predominantly involving skin and joints. It has inflammatory and hyperplastic effect on skin, which is characterized by erythema and increased scaly plaques. Psoriasis tends to go through cycles, subsiding or flaring or relapsing, which requires regular and prolonged treatment. It not only affects skin but also social life of the patients causing mental depression and difficult interpersonal relationships. It is common in both male and female genders. Mostly seen in patients with streptococcal infection, psychological stress, etc. It is characterized by infiltration of immune cells, epidermal hyper-proliferation, and abnormal keratinocyte differentiation. Conventional (allopathic) drugs are used to treat various auto-immune disorders. The alternative system of medicine such as Siddha medicine is effective in treating of auto-immune disorders. In order to annotate the anti-psoriatic activity of "Idi Valladhi Mezhugu" This study aims to demonstrate the anti-psoriatic activity of IVM using Psoriasis (HaCat) cell lines. This study uses Siddha formulated Idi Valladhi Mezhuguas an anti-psoriatic medication in in-vitro HaCaT cell line study. In-vitro anti-psoriatic evaluation of test drug IVM on the cell viability against HaCaT keratinocyte cell line was performed at varying concentration ranges from 10 to 200 ?g/ml. The result obtained from the study reveals that the percentage of cell viability of HaCaTcell line viability decreases due to increase in concentration of the test drug IVM. The characteristic effect of psoriasis such as scaly plaques and recurrence rate has substantially decreased as well.