A Case of Chromoblastomycosis

Background: Chromoblastomycosis is a chronic mycosis that affects the skin and subcutaneous tissues and occurs frequently in tropical countries. The clinical picture of chromoblastomycosis often resembles other diseases such as squamous cell carcinoma and verrucous skin tuberculosis so it is often misdiagnosed.There is no standard therapy available for chromoblastomycosis, and little is known regarding the relation between antifungal susceptibility testing and clinical outcome Case: A women, 30 years old, presence of large plaque and verrucous hyperplasia lesions left instep with abnormal activities. The diagnosis of chromoblastomycosis was based on gross and microscopic morphologies, histopathological examination and clinical manifestation. The patient was treated orally with itraconazole (200 mg twice a day). Evaluation after 2 months of treatment has shown improvement. Discussion: Cutaneous and subcutaneous infections of chromoblastomycosis always take place traumatically. The clinical feature of this case is verrucous plaques covered with yellow and thick crusts, which may be misdiagnosed as verrucous skin tuberculosis, squamous cell carcinoma. Sclerotic bodies showed in histopathological examination is the most characteristic of chromoblastomycosis. Currently, there is no accepted treatment guidelines for chromoblastomycosis. In general, the treatment of chromoblastomycosis is difficult, requiring a long duration of continuous systemic antifungal treatment. Itraconazole and terbinafine are the most frequently used antifungal agent for the treatment of chromoblastomycosis, used alone or in combination.