A Clinicopathological Study of Thyroid malignancy in Multinodular Goiter in a Tertiary Care Hospital

Background: Multinodular goiter is a most common endocrine disorder affecting 500 to 600 million people worldwide. In India 54 million people have goiter and estimated risk about 167 million. Incidence of malignancy in multinodular goiter varies from 0.9 to 13%in different parts of world. Among malignancy, Papillary thyroid carcinoma was the commonest malignancy. Most of the cases were diagnosed between the 5th and 6th decade of life and frequently seen in females. Aims and Objectives: 1) To Study age and sex wise incidence 2) To evaluate the various morphological types of thyroid malignancy in multinodular goiter3.To study the thyroidectomy specimens by routine histo pathological examination. Materials and Methods: A Retrospective study done on 136 surgically resected thyroidectomy specimens of multinodular goiterin department of pathology with duration of two years, from January 2020 to December 2021 at santhiram medical College and general hospital, Nandyal, Andhrapradesh, India. Results: Among the 136 cases of multinodular goiter 107(79%) were female and 29(21%) were male. Histopathological examination shows, benign multinodular goiter present in 124 (91%) cases. Malignant thyroid lesion in 12 (9%) cases. Among malignancies, Papillary thyroid carcinoma was the commonest malignancy. Conclusion: Multinodular goiter could be assign of different types of thyroid malignancy. Most common type was papillary carcinoma.