Synthesis, Characterization, and Computational Study of Novel Thiazolidinone Derivatives Containing the Indole

The present study includes the synthesis and characterization of thiazolidinedion containing indole ring. Two compounds were prepared: (4-fluorophenyl)-2-(1H-indol-3-yl)thiazolidin-4-one (I) and(4-( dimethylamino)phenyl)-2-(1H-indol-3-yl)thiazolidin-4-one(II), the prepared compounds  diagnosed by using infrared spectra, NMR spectra (1H-NMR), and the results were identical to what is expected in practice. The Gaussian program was used for the computational study of thiazolidinedion and the theoretical calculations of the thermodynamic variables showed that compound (I) is the more softness with the lowest hardness. Meanwhile, compound (II) the more hardness with less softness.