Synthesis and Characterization of New Thiazolidinone and Oxazolidinone Heterocyclic Derivatives from 2-Marcapto-1,3,4-Thiadiazole Compounds

The previous effort involved the synthesis of unprecedented Schiff's bases compounds of hydrazine hydrate linked with ethyl 4-hydroxybenzoate, which in turn reacted with carbon disulfide (CS2) and potassium hydroxide (KOH) as catalyst to synthesize 2-marcapto-1,3,4-thiadiazole which reacts with methyl bromoacetate in the presence of triethyl amine N(CH2CH3)3 to form an ester whose methoxy group is converted into a hydrazide, and then reacts with different aromatic aldehydes to form Schiff bases, from which the thiazolidinone and oxazolidinonefive-membered ring heterocyclic compounds' derivatives were formed. All synthetic substances have high yields. The melting points of all compounds and some of their 1H-NMR and FT-IR spectra, were used to authenticate their identities.