Comparison of Preangiography Haemogram-Derived Inflammatory Indices (HDII) Between Non-STElevation Acute Coronary Syndrome (NSTE-ACS) and Chronic Coronary Syndrome (CCS) Patients

This study aimed to compare the preangiography Haemogram-Derived Inflammatory Indices (HDII), such as neutrophil-tolymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) between patients with Non-ST-Elevation Acute Coronary Syndrome (NSTE-ACS) and Chronic Coronary Syndrome (CCS) undergoing Percutaneous Coronary Intervention (PCI), and investigate the correlation of above-mentioned Indices with clinical and angiographic risks evaluated by the GRACE (Global Registry of Acute Coronary Events. Version 2) admission-6-month mortality and the SYNTAX risk scores for patients with ACS. Methods. All essential laboratory tests and Haemogram-Derived Inflammatory Indices (HDII) calculations were performed during the first hour of admission, before percutaneous coronary intervention (PCI) in 100 patients with Non-ST-Elevation Acute Coronary Syndrome (NSTEACS) and 91 patients with Chronic Coronary Syndrome (CCS). The clinical and angiographic risks were assessed by the GRACE and SYNTAX scores, respectively, in the group of patients with NSTE-ACS. Results. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were significantly higher in patients with Non-ST-Elevation Acute Coronary Syndrome (9.79 ± 6.33 vs 2.61 ± 1.39, 0.80 ± 0.58 vs 0.36 ± 0.19, and 262.2 ± 166.2 vs 141.0 ± 66.8, respectively. p<0.0001). The GRACE risk score was 1.4- times higher in the group with a high NLR quantile (7.050±0.1929 95% CI [6.667 to 7.433]) compared to those with low NLR (4.985±0.1708 95% CI [4.646 to 5.324], p<0.0001). The SYNTAX score was 1.6-times higher in the group with a high NLR quantile (1.414±0.0934 95% CI [1.229 to 1.600] vs 0.884±0.0541 95% CI [0.776 to 0.991], p<0.0001). Conclusions. According to the results of the present study, elevated periprocedural Haemogram-Derived Inflammatory Indices (HDII) indicate a more intense inflammatory and prothrombotic state in patients with Non-ST-Elevation Acute Coronary Syndrome (NSTE-ACS) compared to patients with Chronic Coronary Syndrome (CCS), but only neutrophil-to-lymphocyte ratio (NLR) is positively and significantly correlated with clinical and angiographic risks measured by GRACE and SYNTAX tools, respectively.