Prevalence And Antibiotic Resistance Pattern Of Linezolid And Vancomycin Resistant Gram-Positve Cocci Isolated From Surgical Site Infections

The aim of this study was to determine the prevalence and antimicrobial resistance profiles of Gram-positive cocci isolated from surgical site infections. Out of 320 bacterial isolates, 268 (83.75%) were identified as Staphylococcus spp. and 52 (16.25%) were identified as Enterococcus spp. Among staphylococci, 71.64% were coagulase-positive and 28.36% were coagulase-negative. The antimicrobial resistance of all isolates was tested with a disc diffusion method. The majority (69%) of coagulase-positive staphylococci were methicillin-resistant Staphylococcus aureus (MRSA) while 31% were methicillin-sensitive Staphylococcus aureus (MSSA). All staphylococci were found to be susceptible to vancomycin and only two isolates were found to be resistant to linezolid. On the other hand, high level (28%) of resistance to vancomycin was observed in enterococci and no enterococcal isolates exhibited resistance towards linezolid. Results revealed that all investigated isolates were resistant to ampicillin and tetracycline. High prevalence of erythromycin and ciprofloxacin resistance was observed in 91 and 77% of isolates, respectively, while only 18 and 28% of the isolates were resistant to amikacin and clindamycin, respectively.