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Microbial Iron Chelators: A Possible Adjuncts for Therapeutic Treatment of SARS-CoV-2 like Viruses

Journal: Advanced Journal of Chemistry-Section A (Vol.6, No. 1)

Publication Date:

Authors : ; ; ;

Page : 65-70

Keywords : Iron chelator; Siderophore; Desferrioxamine E; SARS-CoV-2; Molecular docking;

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Abstract

There is a need for targeted, effective antiviral therapeutic treatment for the global threat of COVID-19, like viral pandemics. Our efforts in this direction present the in-silico testing of a hypothesis through molecular docking. We have demonstrated the possibility of a microbial siderophore desferrioxamine-E produced by Pseudomonas stutzeri SGM-1 for effective drug targeting and drug development against SARS-CoV-2, like viruses. Iron homeostasis and COVID-19 have a close relationship. An iron chelator desferrioxamine-E binding with the SARS-CoV-2 virus can inhibit the viral RNA binding and packaging into the new virions inside the host cell. The well-known efficacy of iron chelation and RNA binding domain of SARS-CoV-2 nucleocapsid interaction of desferrioxamine-E studied through molecular docking has promising potential for exploring microbial iron chelators as adjuncts for in-silico clinical trials and randomized clinical trials.

Last modified: 2022-12-23 14:33:55