Microbial Iron Chelators: A Possible Adjuncts for Therapeutic Treatment of SARS-CoV-2 like Viruses
Journal: Advanced Journal of Chemistry-Section A (Vol.6, No. 1)Publication Date: 2023-01-01
Authors : Swapnil Mahajan; Muntjeeb Syed; Shridhar Chougule;
Page : 65-70
Keywords : Iron chelator; Siderophore; Desferrioxamine E; SARS-CoV-2; Molecular docking;
Abstract
There is a need for targeted, effective antiviral therapeutic treatment for the global threat of COVID-19, like viral pandemics. Our efforts in this direction present the in-silico testing of a hypothesis through molecular docking. We have demonstrated the possibility of a microbial siderophore desferrioxamine-E produced by Pseudomonas stutzeri SGM-1 for effective drug targeting and drug development against SARS-CoV-2, like viruses. Iron homeostasis and COVID-19 have a close relationship. An iron chelator desferrioxamine-E binding with the SARS-CoV-2 virus can inhibit the viral RNA binding and packaging into the new virions inside the host cell. The well-known efficacy of iron chelation and RNA binding domain of SARS-CoV-2 nucleocapsid interaction of desferrioxamine-E studied through molecular docking has promising potential for exploring microbial iron chelators as adjuncts for in-silico clinical trials and randomized clinical trials.
Other Latest Articles
- A 2-D QSAR Modeling, Molecular Docking Study and Design of 2-Arylbenzimidazole Derivatives as Novel Leishmania Inhibitors: A Molecular Dynamics Study
- Perspective on Metal-Ligand Coordination Complexes and Improvement of Current Drugs for Neurodegenerative Diseases (NDDs)
- (S)-N-(4-Carbamoylphenyl)-8-Cyclopropyl-7-(Naphthalen-1-ylmethyl)-5-Oxo-2,3-Dihydro-5H-Thiazolo[3,2-a]Pyridine-3-Carboxamide, A Better Inhibitor of SARS-Cov-2 Spike Glycoprotein Than Some Standard Drugs: A Computational Prediction
- Production of Methyl Ester from Used Cottonseed Oil Optimized Using Box Behnken Design Approach
- MICROFLORICULTURE SOUVENIR CREATIVE INDUSTRY: FEASIBILITY STUDY
Last modified: 2022-12-23 14:33:55