Transdermal Patches of Ramipril an Attempt to Improve Patient Compliance

Background: The present research work is an attempt to develop and evaluate matrix-type transdermal therapeutic system of Ramipril in order to improve patient compliance by sustaining its action. Method Transdermal patches were developed with different ratios of hydrophilic (HPMC) and hydrophobic (EC) polymer combinations. The Fourier transform infrared spectroscopy was used to confirm compatibility. Seven transdermal patch formulations (F1, F2, F3, F4, F5, F6 and F7) consisting HPMC E5 and EC in the ratios of 0:1,1:1,1:2,1:3,1:4,1:5,1:9 respectively were prepared by solvent evaporation technique. All formulations carried Dimethyl sulphoxide as penetration enhancer and Di butyl phthalate as plasticizer in acetone solvent system. The prepared patches were evaluated for in vitro release, moisture absorption, moisture loss and mechanical properties. Key Findings: Combination of polymers HPMC and EC (1:1) showed better release for sufficiently long time and emerged to be ideal formulations for Ramipril. Conclusion The developed transdermal films prolonged release for 24 hrs and thus found useful to improve the patient compliance of Ramipril