FEATURES OF THE LOCAL IMMUNE RESPONSE AND IMMUNOHISTOCHEMICAL MARKERS OF PROGNOSIS IN CERVICAL CANCER
Journal: Journal of the Grodno State Medical University (Vol.20, No. 6)Publication Date: 2023-01-13
Authors : O. V. Shiman V. S. Aliaksinski;
Page : 584-592
Keywords : cervix; cancer; immunohistochemistry; prognosis; local immunity; HPV; p53; p16; Ki67; cyclin D1; CD45; CIN; SIL;
Abstract
According to modern data, cervical cancer (CC) occupies one of the leading places in the structure of malignant neoplasms in women of the Republic of Belarus and the Russian Federation; it is also the fourth most common cancer among women worldwide and the seventh in the general statistics of the incidence of human malignant tumors. Currently, there is a tendency towards an increase in the incidence of cervical cancer among young women, and therefore the problem of diagnosing and evaluating the prognosis of this tumor pathology is becoming increasingly important. The process of carcinogenesis in the cervix has a complex multifactorial nature and includes many biochemical mechanisms. To evaluate them various immunohistochemical markers are used. In order to determine the biological potential of squamous cell carcinoma of the cervix, the researchers have evaluated the role of the expression of p53, Ki67, cyclin D1 and CD45 proteins; these markers have also been supposed to be used as a tool for early cancer diagnosis. However, the data on the role of local immunity in assessing the invasive and metastatic potential of a malignant neoplasm are still extremely scarce. The article presents current literature data on the prognostic role of the expression of immunohistochemical markers in cervical cancer and the features of local immunity in cervical neoplasia.
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