Mental Health, Emotional Stability, and Green-PsychoChemistry through Quality of Life Increased After Treatment for Non-Functioning Pituitary Macroadenomas: - A Systematic Approach

After treatment for a non- functioning pituitary adenoma (NFA) health-related quality of life (HRQoL) improves considerably. However, the literature about the normalization of health-related quality of life after treatment is inconclusive. A concrete conceptualization of the health outcomes of patients with a nonfunctioning pituitary adenoma (NFA) can be helpful to understand the observed variety in HR-QoL outcomes and to improve clinical care and guidance of these patients. For this conceptualization, the Wilson and Cleary model were used. This model has a biopsychosocial character and has been validated in several patients' populations. In this present review, health outcomes of patients with a NFA were described at each stage of the model e.g.,biological, physiological variables, psychological status, symptom status, functional status, general health perceptions and overall HR-QoL. Further improvement of quality of life should be supported by a pituitary specific care trajectory, including psychosocial care (e.g.,self-managementtraining), to beneficially affect characteristics of the patient and the healthcare environment, with the utmost goal to optimize HR-QoL in patients after treatment.