Design and evaluation of aceclofenac microspheres by solvent Evaporation technique.

Background: Aceclofenac is an analgesic and anti-inflammatory drug available as film coated and as topical gel and not been reported in the form of microspheres and it was evaluated in this work. The aim of this study was to formulate and evaluate microspheres aceclofenac microspheres by solvent evaporation technique. Methods: Microspheres were prepared by solvent evaporation method using the polymers Ethyl cellulose, Cellulose acetate and Eudragit RLPO. The prepared microspheres were evaluated for their micromeritic properties, drug content and encapsulation efficiency and characterized by Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The in vitro release studies was performed by pH 6.2, phosphate buffer. Results: The release of Aceclofenac was influenced by the drug to polymer ratio and particle size and was found to be both diffusion and dissolution controlled