Expression of MicroRNA-155-5p in Chronic Kidney Disease as a Potential Marker of Cardiovascular Complications

Background: Chronic kidney disease (CKD) is a silent, serious condition requiring reliable non-invasive markers for diagnosing and predicting complications especially cardiovascular (CV)complications. Objectives: This study aims to detect microRNA-155-5p (miR-155-5p) as a potential marker of CKD and a predictor of CV complications. Subjects and methods: 120 participants were included in this study, and they were categorized as; Group I (n=60, healthy age- and sex-matched control group) and Group II (n = 60, CKD patients). Group II was subdivided into: Group IIA (n = 30 CKD patients without CV complications) and Group IIB (n = 30; CKD patients complicated with CV diseases). Using reverse transcription polymerase chain reaction (RT-PCR), miR-155-5p was detected. Results: miR-155-5p was increased in Group IIA and IIB compared with the control group, while miR-155-5p was increased in Group IIB compared with Group IIA. Conclusion: miR-155-5p can be used as a sensitive and specific marker for detecting CKD and discriminating between CKD with and without CV complications.