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Bi(OTf)3 as a Highly Potent Catalyst for the Synthesis of Mannich Bases under Milder Conditions

Journal: Journal of Applied Organometallic Chemistry (Vol.2, No. 1)

Publication Date:

Authors : ; ; ;

Page : 31-38

Keywords : Bi(OTf)3; one-pot three-component; greener; Mannich reaction;

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Abstract

A simple, eco-friendly friendly and efficient procedure for the synthesis of Mannich Baseshas been developed via multi-component and one-pot reactions of various aldehydes with aniline, and acetophenone and catalytic amount of Bi(OTf)3 reagent in a DCM solvent.The Bi(OTf)3 acts as a highly potent catalyst ( 0.5 to 1 mol%) for a for the synthesis of Mannich base (1,3-diphenyl-3-(phenylamino)propan-1-one). This protocol is also compatible with a variety of hetero aldehyde carbonyl compounds in excellent yields. Thus, this practical method is developed as a notable medium for these derivatives via a multicomponent reaction.

Last modified: 2023-04-18 09:05:27