Design Development and Optimization of Telmisartan’s Ternary Solid Dispersion with Its Formulation

— The current study was conducted to address issues related to the solubility, dissolution, and oral bioavailability of telmisartan, a poorly water-soluble ionizable drug (TMS). The primary goal of this study is to improve Telmisartan solubility using the Solvent evaporation method. To study effect of adsorbents carrier on solubility of drug. Enhancement in dissolution is very crucial for the development of of BCS Class II drugs formulation. This was achieved by use of solvent evaporation method. By Thermal analysis and PXRD it is confirmed that the release rate of Telmisartan by solid dispersion technique using solvent evaporation method is amorphous structure. Furthermore, the weak interactions detected by FTIR spectroscopy between the porous carrier and Telmisartan in solid dispersion contribute to the drug's rapid desorption from the carrier surface upon contact with the dissolution media. This research work concludes that porous carrier particles aid in increasing dissolution rate, including stability studies.