Age-Related Features of Detectability of Xenobiotic Enzyme Gene Polymorphism in Pregnant Women with Fetal Growth Restriction Syndrome |Biomedgrid
Journal: American Journal of Biomedical Science & Research (Vol.8, No. 5)Publication Date: 2020-04-22
Authors : Mavlyanova NN; Najmutdinova DK; Boboev KT;
Page : 431-437
Keywords : Bone fracture; Bone drilling and equipment Specialist; Knowledge transfer; Oil well drilling; Allelic;
Abstract
Fetal growth restriction syndrome (FGRS) is a clinical syndrome caused by morphological and functional changes in the placenta and penetrant by limit of the growth and development of the fetus, its hypoxia, that arise as a result of the combined reaction of the fetus and placenta to various disorders of the pregnant woman. This syndrome is based on pathological changes in the fetal and or uterin-placental complexes with a derangement of the compensatory-adaptive mechanisms at the molecular, cellular and tissue levels. In this case, the transport, trophic, endocrine, metabolic, antitoxic functions of the placenta underlying the pathology of the fetus and newborn are disordered [1-7]. The most significant risk factors of FGRS development include preeclampsia and a combination of pregnancy with extragenital pathology, accompanied by vascular damage. Various etiological factors, affecting at different stages of the development and functioning of the placenta, are ultimately involved in the general pathogenetic mechanism leading to the development of the fetal growth limit syndrome, one of the main manifestations of which is considered a violation of placental circulation - the main function of the placenta [8-16].
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