Cell-Material Interaction - Spreading Course Correlates with Surface Charge |Biomedgrid

To design appropriate materials for tissue engineering, a profound understanding of the cell-material interaction is essential. We are of the opinion that the zeta (ζ) potential has a decisive role in the cell behaviour, outshining wettability. Here we present a comparative analysis of the MG- 63 osteoblastic cell spreading behaviour on negatively and positively charged surfaces in the hydrophilic range. The results indicate a correlation of the cells' spreading area with the surface charge. Thus, the ζ-potential should be considered as a key parameter for cell interactions at the biomaterial interface.