Novel Strategies to Tackle Ras-Related Cancer: An Opinion Based on Two Recent Reviews |Biomedgrid

In this communication, we provide a brief overview of two recent reviews by [1,2] which highlight the importance of the continued need for the development of small molecule inhibitors to modulate abnormal signaling processes stimulated by the Ras GTPases. If not properly regulated, these signaling processes can result in Ras-stimulated hyperactivity that can lead to diseases such as cancer. However, to date, strategies to target inhibition of these proteins still remains a daunting challenge. Therefore, these proteins remain important targets for drug discovery efforts to control Ras-stimulated abnormal cell signaling.