Investigation into the Cytoprotective Potential of Ethanol Extract of DenettiaTripetalain Wistar Rat |Biomedgrid

Epper fruit (Dennettia tripetala) is well known for its wide range of medicinal values which include bowel cleansing, facilitation of digestion and absorption of cholesterol, anti-cancerous effect, anti-microbial effect among many others. But not much has been reported on its cytoprotective effect on the gastric mucosa in spite its widespread use. The current study therefore focuses on evaluating the cytoprotective effect of the extract in wistar rats. Fifteen (15) rats weighing 160-180g were randomly assigned into three groups of five rats each. Group 1 (control), group 2 (low dose group) and group 3(high dose group). Group 1 received 0.5ml of normal saline while Groups 2 and group 3 (experimental groups) received respective doses of 0.00085ml/g body weight and 0.0017ml/g body weight of the extract. The administration was twice a day and lasted for 28 days. All the animals were allowed free access to normal rat chow and water. At the end of the experimental days, the animals were weighed after they were starved overnight.