Extracellular Vesicles in Hematological Malignancies: Communicators for Resistance and Treatment

Extracellular vehicles (EVs), the secret messengers of a cell, are cell-derived signaling vesicles present in most human fluids. They have been recently discovered and are known as signaling particles or a type of dialogue between cells known as microvesicles, exosomes, and apoptotic bodies. The EVs can carry different types of cargo that can be delivered to recipient cells and lead to changes in the phenotype of a cell which might be useful or harmful. Here, we discuss what these busybody cells are, how they are formed, and what they can do in drug resistance or how they have been used as a therapeutic tool in several hematological malignancies. These miniature molecules are a fascinating new field of research. They can be made artificially as therapeutic agents in the era of personalized medicine for overcoming the relapse of hematological malignancies.