The Effects of Ganoderma lucidum Extract on Hematological Malignancy Cell Lines through Different Mechanisms

Hematological malignancies are one of the main reasons of death all over the world. Despite the introduction of various treatments for hematopoietic malignancies, they have a variety of side effects that eventually lead to disease recurrence. Resistance to treatment is the main challenge for patient recovery; therefore, to minimize the toxicity of the commercially- available drugs, some alternatives are needed. Ganoderma lucidum is one of the most well-known medicinal fungus species recommended by Asian physicians and naturopaths to prevent and treat various diseases, including cancers, due to its bioactive and pharmacological components. The present review aimed at collecting recent findings on the molecular mechanism of action of this fungus in different hematological cancer cell lines and investigating how it exerts its anti-cancer activity in these cells.