Pharmaceutical Formulation Analysis Based on Ion Selective Electrode Determination using Drug of Levamisole and its Application

In this work ion-selective electrode is much simpler, more rapid and more economic than various other analytical methods. Four novel levamisole ion selective electrodes were fabricated, characterized and used for determination of levamisole in pharmaceutical formulations. The proposed sensors incorporated levamisole ammonium reineckate or levamisole potassium tetraiodomercurate ion pair complexes as electroactive materials in PVC matrix membrane and dioctylphthalate or o-nitrophenyloctyl ether as solvent mediators. The sensors exhibited fast and stable near Nernstian cationic response of 57±0.1 mV and 39 ± 0.5 mV/ concentration decade of levamisole in the concentration range of 1.0× 10-6 -1.0× 10-1 M, receptively. The lower limit of detection was 0.21± 0.7 ppm. It was found that sensor based on ammonium renickate as ionic counter and o- nitrophenyloctyl ether was the best and was used throughout this investigation in pH range.