Autoantibody IgG Protects Bone Erosion and Destruction in SLE Arthritis |Biomedgrid

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by high levels of autoantibodies and multiorgan tissue damage [1]. Arthritis is common in patients with SLE [2]. Bone erosion is a remarkable feature in arthritis such as rheumatoid arthritis (RA), but they are usually absent in arthritis of SLE [3]. Thus, this is particularly striking for clinical doctors because synovial biopsies from SLE patients show similar synovial inflammation to those in RA [4]. Tissue deposited lupus IgG displays a key role in initiating inflammation in organ tissue including kidney, brain, skin and liver [5-7].