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Preparation and Characterization of Sodium Alginate- Eudragit E100 Based Systems with Prospective Pharmaceutical Delivery to Application
Journal: Open Access Journal of Pharmaceutical Research (Vol.5, No. 4)Publication Date: 2021-11-11
Authors : Voycheva CH;
Page : 1-4
Keywords : Sodium Alginate; Eudragit E 100; Interpolymer Complexes; Modified Release; Biocompatibility;
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Abstract
Regarding the preparation of a local drug delivery system, the possibility of incorporating an active substance in a matrix system was investigated to prolong the drug release. A complex between sodium alginate and a triple copolymer of dimethyl aminoethyl methacrylate was prepared in the presence of a cross-linking agent- malic acid. The formation of a polyelectrolyte complex was proven by turbidimetry, determining the specific viscosity of the diluted solutions of sodium alginate, EE 100, malic acid with IR spectroscopy.
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