Consumption of Wild Tulsi Leaves May Protect Against Methicillin-Resistant Staphylococcus Aurous (MRSA) Infection!

Nosocomial infections are caused by the evolution of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin- resistant Staphylococcus aureus (VRSA). It is concerning because the prevalence of fluoroquinolone and carbapenem resistance in commensal gut bacteria like E. coli is steadily increasing. The emergence of resistant bacterial strains is a natural incidence that happens when microorganisms replicate themselves incorrectly or when resistance features are transferred across strains via horizontal gene transfer pathways. This research demonstrates that leaf juice of Ocimum gratissimum contains a large quantity of flavanoids and phenolic compounds i.e., 315.96 mg rutin equivalent/g dry weight and 0.19 mg GA equivalent/g dry wt. Furthermore, despite its minimal concentration of juice, a notable antibacterial activity found against MRSA stains in comparison to another gram positive and gram-negative bacteria. According to the findings, the zones of inhibition against E. coli, Streptococcus aureus, and MRSA were 2.52 mm, 2.82 mm, and 3.45 mm, respectively.