Physical Guidance of Cultured Retinal Neurons Using Zig-zag Surface Patterns |Biomedgrid
Journal: American Journal of Biomedical Science & Research (Vol.11, No. 3)Publication Date: 2020-12-15
Authors : Saba Moslehi; William J Watterson; Conor Rowland; Julian H. Smith; Maria-Thereza Perez; Richard P Taylor;
Page : 219-221
Keywords : Fractal; In Vitro; Physical Cues; Retinal Neurons; Su8;
Abstract
The use of physical cues to control and guide various types of cells in vitro, especially neurons and their processes, has been the focus of a large amount of research. The response of neuronal processes to artificial surfaces depends on a number of factors including the cell type, the surface chemistry of the material, and the surface's topological features [1,2]. In this Opinion piece, we investigate the extent to which retinal neuronal processes can be made to follow straight lines patterned into a surface. We show they can follow lines with relatively shallow heights of 2 μm and be made to undergo directional changes as great as 50°. However, some processes leave the lines and assume a weaving trajectory as they grow into the surface's unpatterned regions. Based on these findings, we propose that neuronal processes will follow lines more closely if their shapes mimic the fractal weave patterns of unrestricted neurons.
Other Latest Articles
- For Early Diagnosis of Neurodegenerative Diseases: Acting of Biomarkers |Biomedgrid
- Multiple Endocrine Neoplasia Type 2B Due to the M918T Mutation de Novo at Algiers |Biomedgrid
- Lost in Translation? From Conventional Scoring Tools to Modern Data-Driven Risk Assessment in Critical Care Medicine |Biomedgrid
- Cellular Mechanisms of Chromosomal Damage in Fish Models During the Early Steps of Carcinogenesis. Does Gender have an Effect? |Biomedgrid
- Research of Gestational Risk by Primary Health Care Professionals in Brazil |Biomedgrid
Last modified: 2023-07-19 22:04:12