Targeting IL-6 To Calm the Cytokine Release Storm: A Review and Perspective |Biomedgrid

Cytokine release syndrome (CRS) or cytokine storms can affect many body systems and potentiate life-threatening respiratory distress. Various etiologies can elicit a CRS response such as SARS-CoV-2 infection (Corona Virus Disease 2019; COVID-19), E-cigarette, and Vaping Associated Lung Injury (EVALI), and immune-related adverse events in patients receiving effector cell therapies or immune checkpoint inhibitors. CRS does not occur in all patients thus managing the condition is a challenge. We explore the treatment of CRS across various scenarios to establish a novel approach based on various immunologic parameters and possible activation of cytokines.