A Review on Solid Self Micro emulsifying Drug Delivery System A Method for Enhancement of Oral Bioavailability

Arly 40 of new drug candidates possess low aqueous solubility, which is a challenge in development of optimum oral solid dosage form in terms of formulation design and bioavailability of new pharmaceutical products. In recent years, lipid solutions, emulsions and emulsion pre concentrates, which can be prepared as physically stable formulations suitable for incorporation of such poorly soluble drugs are gaining attention. Among lipid based formulations, self micro emulsifying formulations with droplet size 100 nm are capable to improve the oral bioavailability of hydrophobic drugs primarily due to their efficiency in facilitating solubilization and in presenting the hydrophobic drug in solubilized form whereby dissolution process can be circumvented. Self micro emulsifying drug delivery systems SMEDDS are physically stable isotropic mixture which are easy to manufacture and can be filled in soft gelatin capsules and capable to generate a drug containing micro emulsion with a large surface area upon dispersion in the gastrointestinal tract. The micro sized emulsion will facilitate the absorption of the drug due via intestinal lymphatic pathway and by partitioning of drug into the aqueous phase of intestinal fluids. Some disadvantages are possessed by Conventional SMEDDS which are prepared in a liquid form. So solid SMEDDS S SMEDDS prepared by solidification of liquid semisolid self micron emulsifying systems into powders, tablets, pellets etc have gained popularity. In this review, an overview of SMEDDS, their solidification techniques and various factors that potentially affect the oral bioavailability of such drugs are presented. Bhondve Riya R | Kakade Sujit S | Bhosale Ashok V "A Review on Solid Self Micro-emulsifying Drug Delivery System: A Method for Enhancement of Oral Bioavailability" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-3 , June 2023, URL: https://www.ijtsrd.com.com/papers/ijtsrd56288.pdf Paper URL: https://www.ijtsrd.com.com/pharmacy/pharmaceutics/56288/a-review-on-solid-self-microemulsifying-drug-delivery-system-a-method-for-enhancement-of-oral-bioavailability/bhondve-riya-r