Antiplatelet activity of methanol extracts of Rhizoplaca melanophthalma and Umbilicaria krascheninnikovii, two saxicolous lichens from the Maule Region, Chile |Biomedgrid

Globally, there has been little research on the antiplatelet activity of lichen extracts. The studied species occur in areas exposed to stressful conditions, such as extreme temperatures, snow cover during winter and high solar radiation during the summer, which makes them candidates for synthesizing metabolites of biological interest. This aimed to assess the antiaggregant activity of methanol extracts of the lichen species Rhizoplaca melanophthalma (DC) Leuckert (Lecanoraceae) and Umbilicaria krascheninnikovii (Umbilicariaceae) against ADP and TRAP-6, two important platelet agonists. In this work was determined the IC50 for R. melanophthalma and identify compounds of the two species potentially responsible for antiplatelet activity. Lichen material was ground to a fine powder and submitted to extraction using methanol as a solvent.