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Migration of OxLDL+ Macrophage Phenotypes from Pericoronary Adipose Tissue to Coronary Intima: A Possible Mechanism for Human Coronary Atherosclerosis |Biomedgrid
Journal: American Journal of Biomedical Science & Research (Vol.12, No. 3)Publication Date: 2021-03-22
Authors : Yasumi Uchida; Yasuto Uchida; Ei Shimoyama; Nobuyuki Hiruta; Tsuyoshi Tabata;
Page : 247-257
Keywords : Human coronary plaques; Immunohistochemical staining; Macrophage phenotypes; Oxidized low-density lipoprotein; Pericoronary adipose tissue;
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Abstract
We previously found that oxidized low-density lipoprotein (oxLDL), a core atherogenic protein, is stored in human pericoronary adipose tissue (PCAT) and macrophages residing in PCAT accumulate oxLDL. Here, we aimed to identify whether and how the macrophage phenotypes transport oxLDL from PCAT to the coronary intima.
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