Patterns of Genetic Structure and Evidence of Gene Flow between Arabian Peninsula and European Populations |Biomedgrid

The genetic interaction was observed between Asian and European populations. However, genetic admixtures among Eurasians, particularly between East Asians and North western Europeans have been reported but population admixture and gene flow between Arabian Peninsula and European populations have been poorly studied at the level of genome. Here, we have compared the whole-exome sequencing of 1208 individuals from the Arabian Peninsula, Africa, Europe, Caucasian, East and South Asia, to identify genetic structure and gene flow between them. We have shown that there is less differentiation between Arabian Peninsula and Italy samples than that between the Arabian Peninsula and other Europeans in this study. As well as Italy samples exhibit higher similarity of copy number variation of deletion and duplication with Qatari individuals. Arabian Peninsula ancestry expanded into the South Asian, Caucasian and parts of European populations. Large identity by descent tracts (≥ 2.0 cM) were identified between Arabian Peninsula and individuals from Kenya and Nigeria.