Ageing and Increasing Doses are Factors Related to Delays for Adults with Haemophilia to Seek Prophylactic Clotting Factors |Biomedgrid

Adherence to prophylaxis influences the effectiveness of the haemophilia treatment. This retrospective single-centre cohort study aimed to identify factors related to delay to seek prophylactic factor for home treatment in people with severe and moderate haemophilia (PwHsm). Medical and pharmacy files were reviewed. A person who delayed ≤ 25% days to seek factor during a period of 12 scheduled dispensations was considered as adherent to seek the factor. Among 103 PwHsm, 53% were non-adherent to seek clotting factor. In the children/adolescents subgroup, delay was associated to haemophilia B. In the adult subgroup, both the age and the mean dose were directly associated with non-adherence. Children/ adolescents with haemophilia B delay longer to seek coagulation factors for prophylaxis, while adult PwHsm tend to delay with increasing age and increasing prophylactic dose to be infused. The interdisciplinary team should develop age-based strategies to ensure the patient will receive the prophylactic clotting factor at the scheduled time.