Roles of Autophagy in Regulating ER Stress-Mediated Type 2 Diabetes |Biomedgrid

Type 2 diabetes (T2D) is a metabolic disorder closely associated with endoplasmic reticulum (ER) stress mediated β-cells loss and/or dysfunction and insulin resistance. On the other hand, ER stress and autophagy are strongly interconnected to maintain cellular homeostasis under metabolic stress and environmental cues. Therefore, co-targeting autophagy and ER stress is a promising strategy for T2D treatment.