The Correlation between CYP2R1 rs10741657 and CYP27B1 rs10877012 Gene Polymorphism with the Incidence of Latent Tuberculosis Infection on Pregnant Mothers with Vitamin D Deficiency

Background: Vitamin D levels are affected by several vitamin D metabolism gene. The genetic variations of vitamin D metabolism gene, such as the CYP gene, plays a role in the first and the second vitamin D hydroxylation pathway, in which this will affect the levels of vitamin D serum. Low levels of vitamin D can play a role in the risk development of chronic infection diseases, and even malignancy; one of the aforementioned infections is the M. tuberculosis infection, so that on pregnant with LTBI are at a higher risk of developing into an active TB infection, especially if they are experiencing vitamin D deficiency. Methods: The design used in this study is a case control study that follows 84 pregnant mothers on their third trimester from three hospitals in Medan, North Sumatera. The subject of this study is 42 pregnant mothers with LTBI and 42 pregnant mothers without LTBI. This study was conducted throughout December 2021 until July 2022. The assessed parameters are the IGRA and the vitamin D levels on pregnant mothers, which then will be further correlated with the CYP2R1 rs10741657 and CYP27B1 rs10877012 gene polymorphism. Further analysis utilized the Chi-squared test and the Fisher test. Results: This study reported that 42,85% pregnant mothers with LTBI experienced vitamin D deficiency. This study also reported that there is not a significant correlation between CYP2R1 rs10741657 and CYP27B1 rs10877012 gene polymorphism and vitamin D levels (p = 0.541 and 0.057), and there is not a signification correlation between CYP2R1 rs10741657 and CYP27B1 rs10877012 gene polymorphism and the incidence of LTBI (p = 0.03; p = 0.001). Conclusions: There is no signification correlation between CYP2R1 rs10741657 and CYP27B1 rs10877012 gene polymorphism on the incidence of LTBI and the vitamin D levels on pregnant with LTBI.