DEVELOPMENT AND CHARACTERIZATION OF FLURBIPROFEN LOADED NIOSOMAL IN-SITU GEL FOR OPHTHALMIC DRUG DELIVERY SYSTEM

Niosome are non-ionic surfactant-based liposomes, obtained in the hydration of artificial non-ionic surfactants, without or with addition of cholesterol or additional lipids. The intention of the current study was to organize and evaluate the in-situ niosomal gel loaded with flurbeprofen for the ophthalmic drug delivery system. Flurbeprofen, a nonsteroidal anti- infammatory drug (NSAIDs) is used to relief pain and inflammation. It carries out anti- inflammatory, analgesic and antipyretic activities. Flurbeprofen loaded Niosomes investigate the connection among the non-ionic drug / surfactant ratio with the adding of cholesterol was successfully organized with the thin film hydration way and compare the result of different grade of span used (20, 40 and 60) with the different ratio of cholesterol. Niosomes have been identified by drug entrapment efficiency, drug content, particle size and in-vitro diffusion study. Niosomes prepared using span 60 and cholesterol in the ratio (1:1) f4 showed greater entrapment efficiency (79.2%).