A Review of Azathioprine-Allopurinol Co-Treatment for Ulcerative Colitis |Biomedgrid

One of the most significant inflammatory causes of rectal bleeding is Ulcerative colitis (UC). This disease primarily impacts the colon, typically causing continuous mucosal ulcerations in the rectum extending proximally into the large intestine. Although believed to not be as severe as Crohn's disease, Ulcerative colitis has a slightly greater prevalence in North America. Aside from bloody diarrhea, symptoms of UC include left lower quadrant abdominal pain before bowel movements, rectal urgency, fever, and weight loss. Extra-intestinal complications such as ocular disease, arthralgias, and primary sclerosing cholangitis contribute significantly to the morbidity of this disease [1].