Implication of Plasma miR 122 and miR 151-3p Levels in Diagnosis and Prognosis of Acute Coronary Syndrome Patients

Background: Acute coronary syndrome (ACS) has a significant morbidity and fatality rate. An early diagnosis and accurate prognosis are necessary. Therefore, biomarkers that are associated with coronary artery stenosis and hazard for coronary artery disease (CAD) development are far required. The objective of the current study is to identify the role of plasma miR-122 and miR 151-3p as diagnostic and prognostic indicators in patients with ACS. Methods: A total of 100 Egyptian subjects were enrolled that included 25 unstable angina (UA) patients, 25 NSTEMI patients, 25 STEMI patients, and 25 healthy volunteers. Quantitative real-time PCR (RT-PCR) for both plasma miR-122 and 151-3p expression were performed and Cardiac Catheterization had been performed for displaying the severity of stenosis. Results: There was steadily significant elevation in miRNA-122 and miR151-3p levels from control group to STEMI group (p< 0.001). In studied cases, there were substantial positive correlation between both miR-122 and miR 151-3p with cardiac Troponin (p< 0.001) and coronary stenosis (p< 0.001). Conclusion: Both miR-122 and miR-151 -3p were diagnostic biomarkers for ACS and were capable of evaluation of the grade of coronary artery stenosis to expect the necessity for percutaneous coronary intervention (PCI) in medical practice. Moreover, they have prognostic value for adverse cardiac events (ACE).