Dose Response Study of Aqueous Extract of Dialium Guineense Stem Bark |Biomedgrid

Background and Objective: What distinguishes a poison from a remedy is dose. The safety of plant-derived bioactive compounds has become a global concern. The present study investigated the dose response of aqueous extract of Dialium guineense stem bark using Wistar rats. Methods: Adult male Wistar rats (n=30) weighing 160-180 g (mean weight =170 ± 20 g) were randomly assigned to six groups of five rats each. The aqueous extract of the medicinal plant stem bark was obtained using cold maceration method. The rats received varied doses of extract (200-2000 mg/kg body weight, bwt) orally with the aid of gavage for a period of 28 days (4 weeks). Concentration of Fasting Blood Glucose (FBG) was used as the therapeutic index. Results: Aqueous extract of D. guineense stem bark significantly reduced the FBG levels of normal Wistar rats (p<0.05). The graded and quantal dose response curves showed that 1000 mg/kg bwt was effective in reducing the blood glucose of rats (produced the best hypoglycemic effect).