Formulation and Evaluation of Oral Dispersible Tablet of Poorly Water-Soluble Drug ‘Glimepiride’ by Using Solubility Enhancement Technique
Journal: International Journal of Pharmaceutical Sciences and Medicine (IJPSM) (Vol.9, No. 1)Publication Date: 2024-01-30
Authors : Nimisha Solanki; Arpit Gawshinde; Komal Tikariya; Dharmendra Solanki; Umesh K. Atneriya;
Page : 62-72
Keywords : Orodispersible tablet; glimepiride; solid dispersion; solvent evaporation method; direct compression Method and super disintegrating agents;
Abstract
The present study is regarding Glimepiride (GMP) is poorly water-soluble drug. According to the BCS, Glimepiride undergoes Class II - High Permeability and Low Solubility. The objective of the research project is to enhance the solubility of Glimepiride by using solubility enhancement techniques. The endeavor is to improve its solubility by using super disintegrating agent to enhance the ability of disintegration of Oro dispersible tablet. To enhance of solubility of GMP, our select the method i.e. solid dispersion technique because Solid dispersion is an effective way of improving the dissolution rate of poorly water-soluble drugs and hence its bioavailability. The polymers used were PEG 4000 and PEG 6000 for prepared solid dispersions in different ratio by two method i.e. Fusion and solvent evaporation method. The solvent evaporation method is better result of drug for enhancement of solubility. Oral dispersible tablet of Glimepiride was prepared by direct compression method. ODTs of glimepiride by using different super disintegrants such as sodium starch glycolate, cross povidone and croscarmellose sodium. Further, post evaluation parameters like Shape and Color of Tablets, Thickness, hardness, friability, weight variation, Uniformity of Drug Content, In vitro Dissolution Rate Studies and In-vitro disintegration time were also evaluated and the results were discussed.
Other Latest Articles
- A REVIEW: NATURAL POLYMER LOADED MATRIX TABLETS OF ANTIPYRETIC DRUG
- Characterization and Improvement Dissolution Profile of the Hydrochlorothiazide-β-Cyclodextrin Inclusion Complex using Kneading Method
- Development And Validation of An In-House Brucella Smooth Lipopolysaccharide as A Coating Antigen in ELISA For Serodiagnosis of Bovine Brucellosis |Biomedgrid
- The Role of Mutations on Genes OPN1LW, OPN1MW, OPN1SW in Color Vision Deficiency Syndrome |Biomedgrid
- RNA-based Therapeutics in Cardiology: Dawn of a New Era? |Biomedgrid
Last modified: 2024-01-26 02:32:53