Artemether-Lumefantrine in combination with Arthrospira platensis as an Adjunct Therapy on Lipid Profile Parameters and Parasitaemia Levels in Children with Acute Uncomplicated Malaria |Biomedgrid

Malaria being one of the most life-threatening diseases in Africa is of public health importance in Cameroon with Plasmodium falciparum species responsible for over 98% of deaths in children in this endemic zone. Changes in the lipid profile are commonly reported in malaria infected children and the use of artemisinin-based combination therapy has been one of the main strategies to curb the disease but has faced some challenges. Due to this effect, this study aimed to evaluate the effect of Arthrospira platensis (a cyanobacteria which has been known to demonstrate antimalarial and lipid modulatory effects) on the parasitaemia clearance rate and the lipid profile in Cameroonian children below 16 years of age. In an open labeled randomized clinical trial, enrolled participants who had lipid parameters within normal ranges (TC= <200 mg/dL, TG= <150mg/dL, LDL= <150mg/dL, HDL= >60mg/ dL), and individuals who had uncomplicated P.